Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NAD(P)H quinone oxidoreductase 1 (NQO1)
- Target
- NQO1
- Molecular classification
- Enzyme, Flavoprotein
01
Overview
NQO1 is a cytosolic, FAD-dependent flavoprotein enzyme that catalyzes the two-electron reduction of quinones to hydroquinones, using NADH or NADPH as electron donors. This action prevents the formation of semiquinone radicals and reactive oxygen species (ROS). NQO1 plays a crucial role in cellular antioxidant defense, detoxification, and regulation of p53 stability. It is overexpressed in many cancers, making it a therapeutic target for cancer-specific therapies, including the bioactivation of chemotherapeutic prodrugs.
02
Mechanism of action
Inhibition of NQO1 activity via dicoumarol; induction of NQO1 expression via dioxins and other compounds; bioactivation of prodrugs in cancer cells.
03
Biological functions
DetoxificationAntioxidant defensep53 stabilization
04
Disease associations
CancerOxidative stress-related diseases
05
Safety considerations
Potential for off-target effects due to widespread expression; induction of NQO1 may have complex consequences depending on cellular context.
06
Interacting drugs
Dicoumarol
1 more in the full profile.
07
Biomarkers
NQO1 expression levels in tumor tissue
Beyond the preview
Go deeper on NAD(P)H quinone oxidoreductase 1 (NQO1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NAD(P)H quinone oxidoreductase 1 (NQO1).