Target intelligence / Profile preview

NAD(P)H quinone oxidoreductase 2 (NQO2)

Target: NQO2
Molecular classification: Enzyme, NAD(P)H dehydrogenase (quinone), Flavoprotein

Overview

NAD(P)H quinone oxidoreductase 2 (NQO2), also known as QR2, is a cytosolic flavoprotein enzyme that catalyzes the two-electron reduction of quinones to hydroquinones using dihydronicotinamide riboside (NRH) as an electron donor. It plays roles in phase II detoxification pathways and has been associated with neurodegenerative diseases and several cancers.

Other names: QR2NMOR2NRH:quinone oxidoreductase 2Ribosyldihydronicotinamide dehydrogenase [quinone]

Mechanism of action

Catalyzes the two-electron reduction of quinones to hydroquinones using dihydronicotinamide riboside (NRH) as an electron donor.

Biological functions

Detoxification of xenobiotics/oxidative stress protectionMemoryBiosynthesis including vitamin K-dependent carboxylationElectron carrier activityDihydronicotinamide riboside quinone reductase activityMetal ion binding

Disease associations

Neurodegenerative diseasesCancerBreast cancer

Interacting drugs

Resveratrol

1 more in the full profile.

Beyond the preview

Go deeper on NAD(P)H quinone oxidoreductase 2 (NQO2).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on NAD(P)H quinone oxidoreductase 2 (NQO2).

Explore the full profile