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Target intelligence / Profile preview
NAD-dependent deacetylase sirtuin 1 (SIRT1)
- Target
- SIRT1
- Molecular classification
- Enzyme, Protein deacetylase
01
Overview
NAD-dependent deacetylase sirtuin 1 (SIRT1) is a highly conserved enzyme that plays a central role in cellular regulation, metabolism, and stress response. It regulates numerous physiological processes through deacetylation of histones and non-histone proteins, impacting chromatin structure, gene expression, and the activity of transcription factors. Its activity is tightly regulated by cellular NAD+ levels and interactions with binding partners. Altered SIRT1 function has been linked with metabolic disorders, inflammatory diseases, neurodegenerative diseases, cancer, cardiovascular disease, and aging.
02
Mechanism of action
Deacetylation of histones and non-histone proteins
03
Biological functions
Regulation of energy metabolismModulation of chromatin structureRegulation of gene expressionRegulation of insulin secretionStress response
04
Disease associations
Diabetes mellitus type IIInflammatory diseasesNeurodegenerative diseasesCancerCardiovascular diseaseAging
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