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Target intelligence / Profile preview
NAD-dependent protein deacetylase sirtuin-2 (SIRT2)
- Target
- SIRT2
- Molecular classification
- Enzyme, Histone modification, Class III HDAC, NAD+-dependent protein deacetylase
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Overview
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) is an enzyme that belongs to the sirtuin family of proteins. It is a class III histone deacetylase that utilizes NAD+ to deacetylate both histone and non-histone proteins, influencing a variety of cellular processes including cell cycle control, metabolism, and autophagy. It is ubiquitously expressed but highly abundant in metabolically active tissues like the brain. SIRT2 primarily resides in the cytoplasm but can translocate to the nucleus under certain conditions. Its dysregulation has been implicated in several diseases, including neurodegenerative diseases, cancer, and metabolic disorders.
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Mechanism of action
NAD+-dependent deacetylation of lysine residues on target proteins via ADP-ribosyl peptidyl-imidate formation.
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Biological functions
DeacetylationCell cycle controlRegulation of microtubule acetylationControl of myelinationModulation of gluconeogenesisRegulation of autophagy/mitophagyMaintenance of genomic stabilityMetabolic regulationRegulation of chromosome condensation
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Disease associations
Neurodegenerative diseaseCancerMetabolic disordersDiabetesObesity
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Safety considerations
Context-dependent tumor suppressor or promoter activityDysregulation may lead to defects in cell proliferation/cycle checkpoints or increased susceptibility to oxidative damage.
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Interacting drugs
AGK2
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