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NAD-linked enzyme
- Molecular classification
- Enzyme
01
Overview
NAD-linked enzymes are a class of enzymes that utilize nicotinamide adenine dinucleotide (NAD) as a coenzyme in their catalytic activities. They are essential for cellular metabolism, particularly in redox reactions, energy production, DNA repair, and cell signaling. They use NAD⁺ or NADH to transfer electrons during metabolic reactions and are critical for processes such as glycolysis, the citric acid cycle, oxidative phosphorylation, DNA repair via PARPs, and gene regulation via sirtuins. Reduced levels or dysregulation are linked to aging, neurodegeneration, metabolic disorders, and cancer.
02
Mechanism of action
Electron transfer via oxidation/reduction using NAD+/NADH; enzyme activation
03
Biological functions
Redox reactionsCellular energy productionDNA repairRegulation of gene expressionCellular stress response
04
Disease associations
AgingNeurodegenerative diseaseMetabolic disordersCancer
05
Safety considerations
Dysregulation of NAD metabolismPotential for off-target effects due to broad involvement in cellular processes
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