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Target intelligence / Profile preview
NADH–ubiquinone oxidoreductase chain 1 (ND1)
- Target
- ND1
- Molecular classification
- Enzyme, Mitochondrial Protein, Respiratory Chain Complex I subunit
01
Overview
NADH–ubiquinone oxidoreductase chain 1 (ND1) is a core subunit of mitochondrial respiratory chain Complex I, essential for electron transfer from NADH to ubiquinone, coupled with proton translocation across the inner mitochondrial membrane. It plays a critical role in cellular energy production through oxidative phosphorylation. Mutations in ND1 are associated with various human diseases.
- Other names
- MT-ND1NADH-ubiquinone oxidoreductase chain 1
02
Mechanism of action
Inhibition of NADH-ubiquinone oxidoreductase activity
03
Biological functions
Electron transportProton translocationOxidative phosphorylationATP synthesis
04
Disease associations
Leber's hereditary optic neuropathy (LHON)Mitochondrial disorders
05
Safety considerations
Mutations can lead to impaired oxidative phosphorylation and mitochondrial dysfunction
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