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NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5, mitochondrial (NDUFB5)
- Target
- NDUFB5
- Molecular classification
- Enzyme subunit, Respiratory chain protein, Mitochondrial protein
01
Overview
NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5, mitochondrial (NDUFB5), is an accessory subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), the first and largest enzyme complex of the mitochondrial electron transport chain. Located in the inner mitochondrial membrane, NDUFB5 forms part of the transmembrane region of Complex I, which is crucial for transferring electrons from NADH to ubiquinone as part of cellular energy production. While essential for the assembly and structural integrity of Complex I, NDUFB5 itself is not catalytically active. Mutations or dysfunction in NDUFB5 and associated complex I subunits can contribute to mitochondrial and neurodegenerative diseases[1][2][3][5][6][7].
- Other names
- NADH:ubiquinone oxidoreductase subunit B5CI-SGDHSGDHMGC12314Complex I-SGDHNADH-ubiquinone oxidoreductase SGDH subunitcomplex I SGDH subunitCISGDHNADH dehydrogenase (ubiquinone) 1 beta subcomplex516kDacomplex I-SGDH
02
Biological functions
Electron transportMitochondrial respirationOxidative phosphorylation
03
Disease associations
Neurodegenerative diseaseMitochondrial diseaseOther (defects in respiratory chain have been linked to metabolic and degenerative disorders)
04
Safety considerations
Mitochondrial dysfunction risk if complex I assembly or function is disrupted
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