Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 (MT-ND2)

Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 (MT-ND2) is a protein-coding gene that forms a core component of mitochondrial respiratory chain complex I (NADH:ubiquinone oxidoreductase). Located in the inner mitochondrial membrane, MT-ND2 is essential for electron transfer from NADH to ubiquinone, a key step in the mitochondrial electron transport chain, supporting ATP synthesis via oxidative phosphorylation. Pathogenic mutations in MT-ND2 are causally linked to several mitochondrial disorders, especially Leber hereditary optic neuropathy and complex I deficiency, and are implicated as genetic modifiers in a variety of other diseases, including some cancers and neurodegenerative conditions[1][2][3][4][7].

Other names

NADH-ubiquinone oxidoreductase chain 2MTND2NADH2ND2NAD2NADH dehydrogenase subunit 2Complex I ND2 subunitMitochondrial NADH dehydrogenase IINADH-II

Not directly targeted by pharmaceuticals; mechanistic disruption or mutation affects electron transport, leading to mitochondrial dysfunction