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Target intelligence / Profile preview
NADH dehydrogenase subunit 4 (ND4)
- Target
- ND4
- Molecular classification
- Enzyme, Mitochondrial protein, Respiratory chain component
01
Overview
NADH dehydrogenase subunit 4 (ND4), encoded by the mitochondrial genome, is a core subunit of Complex I (NADH:ubiquinone oxidoreductase) in the mitochondrial respiratory chain. It catalyzes electron transfer from NADH to ubiquinone and facilitates proton translocation across the inner mitochondrial membrane, contributing to ATP synthesis. Mutations in ND4 are linked to several diseases, including Leber Hereditary Optic Neuropathy (LHON) and mitochondrial myopathies, due to impaired ATP production.
- Other names
- MT-ND4NADH-ubiquinone oxidoreductase chain 4
02
Mechanism of action
N/A
03
Biological functions
Electron transferProton translocationOxidative phosphorylationRespiratory electron transportATP synthesis
04
Disease associations
Leber Hereditary Optic Neuropathy (LHON)Mitochondrial Myopathy, EncephalopathyAge-related Macular DegenerationMesial Temporal Lobe EpilepsyCystic Fibrosis
05
Safety considerations
Mutations can lead to impaired ATP production and tissue-specific pathologies
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