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Target intelligence / Profile preview
NADH Ubiquinone Oxidoreductase (Complex I)
- Target
- Complex I
- Molecular classification
- Enzyme, Oxidoreductase, Membrane protein
01
Overview
NADH Ubiquinone Oxidoreductase (Complex I) is the first and largest enzyme of the mitochondrial electron transport chain (ETC). It catalyzes the transfer of electrons from NADH to ubiquinone, reducing it to ubiquinol, and couples this with the translocation of protons across the inner mitochondrial membrane. Dysfunction is associated with various hereditary and degenerative diseases due to impaired energy production and increased ROS generation.
- Other names
- NADH:ubiquinone oxidoreductasemitochondrial complex Irespiratory complex I
02
Mechanism of action
Inhibition of electron transfer and/or proton pumping, modulation of ROS production.
03
Biological functions
Electron transportProton pumpingCellular respirationEnergy productionReactive oxygen species (ROS) generation
04
Disease associations
Mitochondrial complex I deficiencyNeurodegenerative diseaseAgingOxidative stressNeuromuscular disorders
05
Safety considerations
Increased ROS production upon dysfunctionPotential for off-target effects due to complex structure and multiple subunitsDrug-induced mitochondrial toxicity
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