NADH-ubiquinone oxidoreductase chain 6 (MT-ND6)

MT-ND6 encodes the NADH-ubiquinone oxidoreductase chain 6, a mitochondrially encoded core subunit of respiratory chain complex I, located in the mitochondrial inner membrane[1][2][5][7]. This protein participates in the transfer of electrons from NADH to ubiquinone as the initial step of the mitochondrial electron transport chain, contributing to ATP synthesis through oxidative phosphorylation[2][5][7]. Mutations in MT-ND6 are associated with mitochondrial diseases such as Leber hereditary optic neuropathy and Leigh syndrome, typically affecting tissue energy metabolism, particularly in highly energy-demanding tissues such as nerves and muscles[1][2][7]. MT-ND6 is essential for the assembly and function of complex I and mutations impairing its function are linked to the production of reactive oxygen species and reduced cellular energy output[1][2][5]. No direct pharmacologic modulators of MT-ND6 are currently approved, but the detection of its mutations is used as a biomarker for mitochondrial disorders.

Other names

NADH dehydrogenase subunit 6complex I ND6 subunitNADH6ND6NAD6MTND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

Not applicable for direct drug targeting (no approved therapies acting directly on MT-ND6); disease mutations disrupt electron transfer and ATP generation, increase reactive oxygen species[1][2][5].