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Target intelligence / Profile preview
NADH:quinone oxidoreductase 1 (NQO1)
- Target
- NQO1
- Molecular classification
- Enzyme, Flavoprotein, FAD-binding protein, Oxidoreductase
01
Overview
NADH:quinone oxidoreductase 1 (NQO1), also known as DT-diaphorase, is a cytosolic flavoprotein enzyme that catalyzes the two-electron reduction of quinones to hydroquinones using NADH or NADPH. This prevents redox cycling and reduces oxidative stress. NQO1 also stabilizes proteins like p53. It is overexpressed in many cancers, making it a potential drug target, while deficiencies increase susceptibility to carcinogens.
- Other names
- DT-diaphoraseEC 1.6.5.2
02
Mechanism of action
NQO1 catalyzes the two-electron reduction of quinones to hydroquinones, preventing the formation of semiquinone radicals and protecting cells from oxidative damage. It can also stabilize proteins like p53.
03
Biological functions
DetoxificationAntioxidant defenseProtection against oxidative stressStabilization of regulatory proteins
04
Disease associations
CancerOxidative stress related diseasesCarcinogenesis
05
Safety considerations
Overexpression in cancer can promote tumor growth and resistance to certain therapies.Reduced or deficient NQO1 expression increases susceptibility to carcinogens.Inhibition of NQO1 may have unintended consequences due to its role in detoxification and p53 stabilization.
06
Interacting drugs
Dicoumarol
1 more in the full profile.
07
Biomarkers
NQO1 expression levelsPro187Ser polymorphism
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