NADH:ubiquinone oxidoreductase subunit A12 pseudogene 1 (NDUFA12P1)

NDUFA12P1 is annotated as a pseudogene—which means it is a gene remnant related to NDUFA12 but is not translated into a functional protein. It is sometimes listed in genomic catalogs due to sequence similarity with functional NDUFA12, but does not have known biological function, clinical significance, or therapeutic relevance. The functional NDUFA12 protein is a non-catalytic accessory subunit of mitochondrial Complex I, involved in electron transport and cellular respiration, with defects linked to mitochondrial diseases such as Leigh syndrome[5][2][1]. However, NDUFA12P1 itself is not functionally expressed, does not interact with drugs, and is not a target for drug development. All canonical information should refer to the functional protein NDUFA12 (not the pseudogene)[5][2][6]. If a functional target is requested, use "NADH:ubiquinone oxidoreductase subunit A12 (NDUFA12)". If referring strictly to NDUFA12P1, the entry should be flagged as incorrect for use as a therapeutic target.

Other names

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 pseudogene 1NDUFA12P1