NADH:ubiquinone oxidoreductase subunit A5 pseudogene 2 (NDUFA5P2)

NADH:ubiquinone oxidoreductase subunit A5 pseudogene 2 (NDUFA5P2) is a processed pseudogene derived from the parental gene NDUFA5, which encodes a subunit of the mitochondrial NADH:ubiquinone oxidoreductase (complex I) enzyme[1][3][5]. NDUFA5P2 is a retrocopy; that is, it originated via reverse transcription of NDUFA5 mRNA and subsequent integration into the genome, resulting in a nonfunctional or non-protein-coding DNA sequence lacking the ability to produce a functional protein[3][5]. Such pseudogenes are recognized as elements in genome evolution, sometimes acquiring regulatory roles, but there is no current evidence that NDUFA5P2 has biological activity, clinical relevance, or therapeutic potential[1][3][5]. NDUFA5P2 is not cataloged in humans, but exists in non-human primate species such as Macaca fascicularis and Rhinopithecus roxellana[3][5]. It is not considered a drug target, biomarker, or protein of clinical significance. Key points regarding "is_target" and "is_incorrect": - NDUFA5P2 is a pseudogene, not a protein-coding gene or expressed receptor/enzyme/target[1][3][5]. - Pseudogenes generally do not encode functional proteins and are not considered therapeutic targets. - NDUFA5P2 is not found in the human genome; it is reported in certain primate genomes[3][5]. - There is no evidence for alternative gene products, protein function, interacting drugs, disease roles, or safety concerns.

Other names

NDUFA5P2 pseudogeneNADH:ubiquinone oxidoreductase subunit A5 pseudogene 2