Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NADP-dependent oxidoreductase domain-containing protein 1 (NOXRED1)
- Target
- NOXRED1
- Molecular classification
- Enzyme, Pyrroline-5-carboxylate reductase family (probable paralog PYCR1)
01
Overview
NADP-dependent oxidoreductase domain-containing protein 1 (NOXRED1) is a probable oxidoreductase enzyme encoded by the human NOXRED1 gene. It is predicted to catalyze the reduction of pyrroline-5-carboxylate, potentially participating in the L-proline biosynthetic pathway, although its precise biochemical function awaits experimental validation. NOXRED1 is expressed in a variety of tissues, with evidence for involvement in cellular metabolic regulation, especially relating to glutamine and proline metabolism. Genomic studies have implicated NOXRED1 variants in patient outcomes for cutaneous melanoma, suggesting a disease-modifying role and possible use as a prognostic biomarker. At present, there are no approved drugs or known drug interactions with NOXRED1, and its direct role as a therapeutic target remains under investigation.
- Other names
- C14orf148FLJ32809Pyrroline-5-carboxylate reductase-like protein C14orf148NXRD1
02
Biological functions
L-proline biosynthetic process (predicted role)Pyrroline-5-carboxylate reductase activity (predicted function)Cellular metabolism, specifically glutamine and proline metabolic pathways in cancer
03
Disease associations
Cancer (especially implicated in cutaneous melanoma; single nucleotide polymorphism affects patient outcome)Visual cortex disease and visual pathway disease (GeneCards clinical association)Other roles not described but expression in many tissues suggests broader potential involvement
04
Biomarkers
SNP rs8012548A>G in NOXRED1 gene is a prognostic marker in melanoma (protective effect, associated with better survival)Expression levels of NOXRED1 mRNA may serve as a biomarker for tumor behavior in melanoma
Beyond the preview
Go deeper on NADP-dependent oxidoreductase domain-containing protein 1 (NOXRED1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NADP-dependent oxidoreductase domain-containing protein 1 (NOXRED1).