NADPH-cytochrome P450 oxidoreductase (POR)

NADPH-cytochrome P450 oxidoreductase (POR), also known as CPR or CYPOR, is a membrane-bound flavoprotein enzyme that transfers electrons from NADPH to all microsomal cytochromes P450 and other heme-containing proteins. This electron transfer is essential for drug metabolism, steroid hormone biosynthesis, cholesterol and fatty acid homeostasis, and the detoxification of xenobiotics. POR consists of an FMN-binding domain, a connecting domain, an FAD-binding domain, and an NADPH-binding domain. It is anchored to the endoplasmic reticulum membrane by a hydrophobic N-terminal transmembrane segment. POR catalyzes sequential electron transfers from NADPH to FAD to FMN to the final acceptor (e.g., cytochrome P450).

Other names

CPRCYPOR

Electron transfer from NADPH to cytochrome P450 and other heme-containing proteins.