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NADPH-dependent enzymes
- Molecular classification
- Enzyme, Oxidoreductase, Dehydrogenase, Monooxygenase, Kinase
01
Overview
NADPH-dependent enzymes represent a large and functionally diverse class of enzymes that use NADPH as a coenzyme or electron donor for metabolic, biosynthetic, and detoxification reactions. This group includes oxidoreductases (such as NADPH oxidases), dehydrogenases, monooxygenases, and kinases, each contributing to fundamental cellular functions ranging from redox maintenance and anabolic synthesis to immune defense. Individual NADPH-dependent enzymes are implicated in disease processes including cancer, inflammation, cardiovascular and metabolic disorders, making select members important drug targets. However, the term "NADPH-dependent enzymes" is an umbrella label and not a suitable representation of a unique, actionable molecular target for drug development.
- Other names
- NADPH-utilizing enzymesNADPH-binding enzymesNADPH-dependent oxidoreductases
02
Mechanism of action
Inhibition of electron transfer to oxygen (NOX inhibitors); Modulation of biosynthetic redox reactions; Blockade of ROS generation
03
Biological functions
Redox homeostasisBiosynthesis (lipids, nucleotides, etc.)Detoxification (e.g. aldehyde dehydrogenases)Immune response (e.g. NADPH oxidase in phagocyte ROS generation)Intermediary metabolism
04
Disease associations
CancerInflammationCardiovascular diseaseOxidative stress disordersMetabolic disordersNeurodegenerative disease
05
Safety considerations
Broad inhibition of NADPH-dependent enzymes may impair cellular redox balance, biosynthesis, and immune functionSpecific inhibitors may have off-target or systemic toxicityRisk of increased susceptibility to oxidative stress and infection
06
Interacting drugs
NADPH oxidase inhibitors (e.g., apocynin, VAS2870)
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