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Target intelligence / Profile preview
NADPH oxidase 1 (Nox1)
- Target
- Nox1
- Molecular classification
- Enzyme, NADPH oxidase
01
Overview
NADPH oxidase 1 (Nox1) is an enzyme that catalyzes the production of superoxide, a reactive oxygen species, using electrons from NADPH. It plays a role in redox signaling, epithelial immunity, and cell growth. Nox1 is implicated in the pathogenesis of atherosclerosis, cancer, and other diseases. ML171 is a selective inhibitor of Nox1.
02
Mechanism of action
Selective inhibition of Nox1 activity by blocking ROS production.
03
Biological functions
Reactive oxygen species (ROS) productionRedox signalingEpithelial immunityCell proliferationCell migrationPost-translational protein processingGene expression regulation
04
Disease associations
AtherosclerosisCancerChronic myelogenous leukemiaVascular injuryDiabetes
05
Safety considerations
Inhibition may impair normal epithelial immunity.Potential for off-target effects on other NADPH oxidases.
06
Interacting drugs
ML171
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