Target intelligence / Profile preview

NADPH Oxidase 2 (NOX2)

Target: NOX2
Molecular classification: Enzyme, Oxidase, Membrane protein

Overview

NADPH oxidase 2 (NOX2) is a multi-component enzyme complex central to innate immunity through its regulated production of reactive oxygen species. Its balanced activity underpins both effective pathogen clearance and prevention of excessive tissue damage linked with inflammatory disorders.

Other names: Cytochrome b(558) subunit betaCytochrome b-245 heavy chaingp91^phox^

Mechanism of action

Inhibition of superoxide production

Biological functions

Reactive oxygen species (ROS) generationPathogen killingRedox signalingImmune responseRegulation of inflammation

Disease associations

Chronic granulomatous diseaseAtherothrombosisInflammatory diseasesAutoimmune diseasesCancer

Safety considerations

Potential for immunosuppressionRisk of infection with inhibitors

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