Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NADPH Oxidase 2 (NOX2)
- Target
- NOX2
- Molecular classification
- Enzyme, Oxidase, Membrane protein
01
Overview
NADPH oxidase 2 (NOX2) is a multi-component enzyme complex central to innate immunity through its regulated production of reactive oxygen species. Its balanced activity underpins both effective pathogen clearance and prevention of excessive tissue damage linked with inflammatory disorders.
- Other names
- Cytochrome b(558) subunit betaCytochrome b-245 heavy chaingp91^phox^
02
Mechanism of action
Inhibition of superoxide production
03
Biological functions
Reactive oxygen species (ROS) generationPathogen killingRedox signalingImmune responseRegulation of inflammation
04
Disease associations
Chronic granulomatous diseaseAtherothrombosisInflammatory diseasesAutoimmune diseasesCancer
05
Safety considerations
Potential for immunosuppressionRisk of infection with inhibitors
Beyond the preview
Go deeper on NADPH Oxidase 2 (NOX2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NADPH Oxidase 2 (NOX2).