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NADPH Oxidase 4
- Molecular classification
- Enzyme, Oxidoreductase, NADPH Oxidase
01
Overview
NADPH oxidase 4 (NOX4) is an enzyme that belongs to the NOX family of NADPH oxidases. It is responsible for generating reactive oxygen species (ROS), primarily hydrogen peroxide (H2O2), from molecular oxygen using NADPH as an electron donor. NOX4 is involved in various cellular processes including redox homeostasis, oxygen sensing, and signal transduction. Its dysregulation is implicated in cardiovascular diseases, cancer, and metabolic disorders, making it a potential therapeutic target.
- Other names
- RENOXKidney oxidase-1 (KOX-1)Renal NAD(P)H-oxidaseKidney superoxide-producing NADPH oxidase
02
Mechanism of action
Small molecule inhibitors or RNA-based therapies aimed at modulating pathological ROS production
03
Biological functions
Redox homeostasisOxygen sensingSignal transductionApoptosis regulationInsulin signaling modulationBone resorption modulationInflammation regulation via NFκB activationGene expression regulation
04
Disease associations
Cardiovascular diseases (hypertrophy/fibrosis)Cancers (esp. PDAC)Metabolic disorders (insulin resistance)Pregnancy complications associated with obesity/metabolic syndrome
05
Safety considerations
Disrupting physiological redox balance while targeting pathological ROS production
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