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NADPH Oxidase Organizer 1 (NOXO1)
- Target
- NOXO1
- Molecular classification
- Enzyme accessory subunit, Organizer protein
01
Overview
NADPH Oxidase Organizer 1 (NOXO1) is a cytosolic protein that functions as an organizer subunit for NOX1 and NOX3 NADPH oxidases. It is essential for their assembly and activation, resulting in the production of reactive oxygen species (ROS), such as superoxide. NOXO1 contains a PX domain for phospholipid binding and two SH3 domains for protein-protein interactions. It plays a role in otoconia biogenesis and modulates Notch signaling via ADAM17 regulation, impacting endothelial cell behavior and angiogenesis. Dysregulation of NOXO1 is implicated in oxidative stress-related diseases, diabetes-related kidney damage, and vascular dysfunction.
- Other names
- P41NOXP41NOXAP41NOXBP41NOXCSH3PXD5SNX28
02
Mechanism of action
Modulates NADPH oxidase activity by organizing and activating NOX1 and NOX3 enzymes, leading to altered ROS production and downstream signaling.
03
Biological functions
Superoxide generationNADPH oxidase complex assemblyProtein bindingPhospholipid bindingRegulation of ADAM17 activityModulation of Notch signaling
04
Disease associations
Oxidative stress-related diseasesDiabetes-related kidney damageVascular dysfunction
05
Safety considerations
Dysregulation can lead to increased oxidative stress and potential cellular damage.Altered ROS production may affect various physiological processes.
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