Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NADPH quinone oxidoreductase 1 (NQO1)
- Target
- NQO1
- Molecular classification
- Flavoprotein enzyme, NAD(P)H dehydrogenase (quinone) family
01
Overview
NADPH quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein enzyme that catalyzes the two-electron reduction of quinones to hydroquinones, preventing the formation of reactive oxygen species. It plays a role in detoxification, antioxidant defense, and stabilization of regulatory proteins like p53. NQO1 is overexpressed in various cancers and is a potential target for pro-drug activation strategies. Polymorphisms in the NQO1 gene are associated with altered susceptibility to oxidative stress-related diseases.
- Other names
- NAD(P)H dehydrogenase [quinone] 1DT-diaphorase
02
Mechanism of action
Two-electron reduction of quinones to hydroquinones, preventing formation of semiquinone free radicals
03
Biological functions
DetoxificationAntioxidant defenseStabilization of regulatory proteinsReduction of quinones to hydroquinones
04
Disease associations
CancerOxidative stress-related diseases
05
Safety considerations
Polymorphisms associated with altered susceptibility to oxidative stressLoss-of-function variants may reduce efficacy/stability of tumor suppressors like p53Potential for pro-drug activation strategies in tumors
06
Interacting drugs
Dicoumarol
07
Biomarkers
Overexpression in cancer cells
Beyond the preview
Go deeper on NADPH quinone oxidoreductase 1 (NQO1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NADPH quinone oxidoreductase 1 (NQO1).