NAIP pseudogene 1 (NAIPP1)

NAIP pseudogene 1 (NAIPP1) is a non-coding pseudogene related to the NLR family apoptosis inhibitory protein (NAIP) gene, found in a region of the genome with multiple NAIP copies and complex genetic rearrangements. Unlike the functional NAIP gene, which encodes a protein involved in inhibiting apoptosis and innate immune response, NAIPP1 is not believed to encode a functional protein. There is speculation that NAIPP1 may function as a competing endogenous RNA (ceRNA) that helps regulate neuronal NAIP transcripts and modulate inflammasome activation in neurons, but this has not been confirmed experimentally[3]. NAIPP1 is not considered a therapeutic target, nor does it fit in well-established molecular target categories such as receptor, enzyme, or transporter. Most available data focus on the functional NAIP gene, not NAIPP1.

Other names

NLR family apoptosis inhibitory protein pseudogene, NAIPP1NLR family apoptosis inhibitory protein pseudogene