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Target intelligence / Profile preview
Nance-Horan syndrome protein (NHS)
- Target
- NHS
- Molecular classification
- Other (actin remodeling regulator, cytoskeletal-associated protein)
01
Overview
Nance-Horan syndrome protein (NHS) is an actin regulatory protein crucial for developmental processes in the eye, teeth, craniofacial skeleton, and brain; mutations cause a multisystem genetic syndrome (Nance-Horan syndrome), but it is not a recognized pharmacological target[1][3][4][10].
- Other names
- NHSActin remodeling regulator NHSNance-Horan syndrome proteinCongenital cataracts and dental anomalies proteinCataract 40 protein (CTRCT40)NHS (congenital cataracts and dental anomalies)
02
Biological functions
Cell morphology regulationActin cytoskeleton remodelingCell-cell junction stabilizationControl of lamellipod formationDevelopment of eye/tooth/craniofacial/brain
03
Disease associations
Congenital cataractsNance-Horan syndrome
04
Biomarkers
NHS gene mutations (diagnostic for Nance-Horan syndrome, X-linked congenital cataracts)
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