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Target intelligence / Profile preview
Nandrolone (19-Nortestosterone)
- Target
- 19-Nortestosterone
- Molecular classification
- Anabolic-androgenic steroid (AAS), Androgen, Progestogen
01
Overview
Nandrolone (19-nortestosterone) is an anabolic-androgenic steroid (AAS) that promotes muscle growth and increases red blood cell production. It acts as an agonist of the androgen receptor (AR) and the progesterone receptor (PR). Nandrolone is derived from prohormones such as 4-norandrostenedione and 4-norandrostenediol through metabolic conversion in the body.
- Other names
- 19-NortestosteroneDurabolin
02
Mechanism of action
Nandrolone binds to the androgen receptor (AR) and progesterone receptor (PR), leading to increased protein synthesis and anabolic effects. Its lower androgenicity compared to testosterone in some tissues is due to its conversion to a less potent metabolite by 5α-reductase.
03
Biological functions
Androgen receptor agonistProgesterone receptor agonistProtein synthesis stimulationMuscle growth promotion
04
Disease associations
Muscle wasting (cachexia)Osteoporosis (potential, off-label use)Anemia (potential, off-label use)
05
Safety considerations
Cardiovascular risks (increased cholesterol, hypertension)HepatotoxicitySuppression of endogenous testosterone productionGynecomastia (estrogenic side effects)Virilization in womenProstate enlargement in menPsychiatric side effects (mood changes, aggression)
06
Interacting drugs
Aromatase inhibitors
3 more in the full profile.
07
Biomarkers
Plasma nandrolone levelsLiver function tests (ALT, AST)Lipid profile (cholesterol, triglycerides)Hemoglobin/Hematocrit
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