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Nanog homeobox protein (NANOG)

Target: NANOG
Molecular classification: Transcription factor

Overview

Nanog homeobox protein (NANOG) is a critical transcription factor involved in the regulation of pluripotency and self-renewal in embryonic stem cells (ESCs). It acts as a master regulator for maintaining ESC identity by promoting self-renewal, imposing pluripotency, and repressing differentiation. Abnormal NANOG activity has been linked to cancer due to its role in promoting cellular immortality.

Other names: Homeobox protein NANOG

Biological functions

Maintains ESC self-renewalMaintains pluripotencySuppresses differentiation signalsRepresses cell determination

Disease associations

Cancer

Safety considerations

Overexpression may contribute to tumorigenesis

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