Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Napsin A aspartic peptidase (NAPSA)
- Target
- NAPSA
- Molecular classification
- Enzyme, Aspartic protease, Peptidase A1 family
01
Overview
Napsin A aspartic peptidase (NAPSA) is an aspartic protease of the peptidase A1 family, predominantly expressed in the lung and kidney[1][2][3][4]. It plays a role in the proteolytic processing of surfactant protein B in alveolar type II pneumocytes and is also involved in protein catabolism in the renal proximal tubules[2][3][7]. Napsin A is primarily used as a biomarker in pathology to distinguish lung adenocarcinomas from other forms of lung cancer and in the diagnosis of certain renal neoplasms[1][2]. It is not currently a direct drug target and has no known therapeutic drugs or characterized mechanisms of pharmacological modulation. Its diagnostic utility is well established in oncology as a tissue biomarker[2].
- Other names
- Napsin-ANAPSANAP1NAPAASP4Asp 4KdapKAPAspartyl protease 4Napsin-1TA01/TA02kidney-derived aspartic protease-like proteinSNAPApronapsin ANR1H2-AS1
02
Biological functions
Protein catabolismProteolytic processing of pulmonary surfactant protein B in lungProtein metabolism in kidneyMembrane protein proteolysis
03
Disease associations
Cancer (notably lung adenocarcinoma, renal cell carcinoma, ovarian clear cell adenofibroma, endometrial clear cell adenocarcinoma)
04
Biomarkers
Lung adenocarcinoma markerRenal cell carcinoma marker
Beyond the preview
Go deeper on Napsin A aspartic peptidase (NAPSA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Napsin A aspartic peptidase (NAPSA).