Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Narrowband Ultraviolet B (NBUVB)
- Target
- NBUVB
- Molecular classification
- Phototherapy, Physical Treatment Modality
01
Overview
Narrowband ultraviolet B (NBUVB) phototherapy is a physical treatment modality that delivers UVB light at 311 nm to the skin. Its primary action is through interaction with cellular DNA, leading to DNA damage, cell cycle arrest, and apoptosis. Additionally, NBUVB induces immunomodulation by suppressing inflammatory cytokines and reducing the activity of immune cells. It is used to treat various inflammatory skin diseases like psoriasis, vitiligo, and atopic dermatitis.
- Other names
- 311 nm UVB phototherapyUVB phototherapy
02
Mechanism of action
NBUVB does not directly target a specific molecule but instead acts by delivering UVB light at 311 nm, which interacts with cellular components in the skin, primarily DNA, to induce photoproducts. This leads to cell cycle arrest, apoptosis, and immunomodulation by suppressing inflammatory cytokines and reducing the activity of immune cells.
03
Biological functions
ImmunomodulationApoptosis inductionCell cycle arrestDNA damage inductionSuppression of inflammatory signaling
04
Disease associations
PsoriasisVitiligoAtopic dermatitisCutaneous T-cell lymphomaInflammation
05
Safety considerations
Skin cancer risk (long-term)PhotosensitivityErythemaPruritus
Beyond the preview
Go deeper on Narrowband Ultraviolet B (NBUVB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Narrowband Ultraviolet B (NBUVB).