Native extracellular matrix remodeling

Native extracellular matrix remodeling refers to the complex and dynamic process by which the extracellular matrix (ECM) within tissues is continuously modified through cycles of synthesis and degradation[1][2][3][4][5]. This process is mediated by numerous enzymes, most notably matrix metalloproteinases (MMPs), ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs), serine proteases (like plasmin and neutrophil elastase), and others[1]. ECM remodeling is essential for development, tissue repair, wound healing, angiogenesis, and maintenance of tissue homeostasis. Dysregulated ECM remodeling contributes to pathological states such as fibrosis, cancer, and chronic inflammation[1][2][3][4][5]. The process is not a discrete target but a modulatory event controlled by a network of interacting proteins, enzymes, growth factors, and cell-surface receptors (such as integrins and discoidin domain receptors)[1][3]. In therapeutics, drugs target individual enzymes or pathways involved in ECM turnover, not the process of "native ECM remodeling" itself. Please note: "Native extracellular matrix remodeling" is not a canonical molecular target but a biological process. Therefore, most structured target data fields are not applicable or require mapping to specific ECM-modifying enzymes or receptors (such as MMPs, integrins, or specific proteases) to fulfill the role of a therapeutic target[1][3].

Other names

ECM remodelingExtracellular matrix remodelingECM degradationMatrix remodeling