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Target intelligence / Profile preview
Native-like HIV Envelope Glycoprotein Trimer (HIV Env trimer)
- Target
- HIV Env trimer
- Molecular classification
- Glycoprotein, Viral protein
01
Overview
The HIV-1 Env trimer is a complex, heavily glycosylated protein composed of three gp120 surface subunits non-covalently associated with three gp41 transmembrane subunits. It mediates virus entry by binding CD4 and co-receptors (CCR5 or CXCR4) on host cells. Stabilized soluble versions are engineered to maintain native-like structure outside membranes. Presenting these trimers as immunogens aims to guide B cell responses toward bnAb precursors by mimicking authentic epitope presentation seen during infection.
- Other names
- SOSIP trimer
02
Mechanism of action
Immunogen to elicit broadly neutralizing antibodies
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune stimulation
04
Disease associations
InfectionHIV infection
05
Safety considerations
Potential for off-target immune responsesChallenges in achieving stable presentationInduction of strain-specific antibodies
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