Natriuretic Peptide Receptor (NPR)

Natriuretic peptide receptors (NPRs) are a family of cell surface receptors that mediate the physiological effects of natriuretic peptides—hormones involved in cardiovascular and renal homeostasis. There are three main subtypes: NPR-A, NPR-B, and NPR-C. NPR-A and NPR-B are guanylyl cyclases that produce cGMP, while NPR-C primarily functions as a clearance receptor. They are involved in vasodilation, natriuresis, diuresis, and skeletal growth regulation, making them therapeutic targets for cardiovascular and skeletal disorders.

Other names

Guanylyl cyclase-A (GC-A)Guanylyl cyclase-B (GC-B)Natriuretic peptide clearance receptor

Agonist binding leads to cGMP production and downstream signaling (NPR-A/B). NPR-C mediates internalization and degradation of natriuretic peptides.