Natriuretic Peptide Receptor 1 (NPR1)

Natriuretic peptide receptor 1 (NPR1) is a membrane-bound guanylyl cyclase that serves as the primary receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). These peptides are potent vasoactive hormones with key roles in cardiovascular and renal homeostasis. Upon ligand binding, NPR1 catalyzes the conversion of GTP to cGMP, leading to vasodilation, natriuresis, and other physiological effects. Dysfunction of NPR1 is associated with heart failure and hypertension, making it a therapeutic target.

Other names

Natriuretic peptide receptor ANPR-AGuanylate cyclase AGC-A

Activation of guanylyl cyclase activity upon ANP/BNP binding, leading to increased cGMP production and downstream signaling.