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Natriuretic Peptide Receptor A (Guanylyl Cyclase A) (NPRA)
- Target
- NPRA
- Molecular classification
- Receptor, Guanylyl Cyclase, Transmembrane protein
01
Overview
Natriuretic Peptide Receptor A (NPRA), also known as Guanylyl Cyclase A (GC-A), is a transmembrane receptor that binds atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). Upon ligand binding, NPRA catalyzes the conversion of GTP to cGMP, leading to vasodilation, natriuresis, diuresis, and inhibition of cardiac remodeling. It plays a crucial role in blood pressure regulation and fluid/electrolyte balance. Elevated plasma levels of ANP/BNP are used clinically as biomarkers for heart failure.
- Other names
- GC-ANPR-ANpr1
02
Mechanism of action
Activation of guanylyl cyclase domain, leading to increased cGMP production.
03
Biological functions
VasodilationNatriuresisDiuresisAldosterone synthesis/secretion inhibitionBlood pressure regulationFluid/electrolyte balanceCardiac remodeling inhibitioncGMP production
04
Disease associations
HypertensionCardiac remodelingHeart failure
05
Safety considerations
Mixed results regarding safety/effectiveness of synthetic analogs for acute decompensated heart failure.Potential off-target effects of synthetic analogs.
06
Interacting drugs
Anaritide
2 more in the full profile.
07
Biomarkers
ANP (plasma levels)BNP (plasma levels)
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