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Target intelligence / Profile preview
Natriuretic Peptide Receptor C (NPR-C)
- Target
- NPR-C
- Molecular classification
- Receptor, Membrane protein
01
Overview
Natriuretic Peptide Receptor C (NPR-C) is a homodimeric membrane receptor that binds ANP, BNP, and CNP. Its primary function is to clear natriuretic peptides from circulation via internalization and degradation. While initially considered biologically silent, NPR-C can also modulate intracellular signaling pathways, including adenylyl cyclase and phospholipase C. NPR-C is widely expressed and plays a role in cardiovascular regulation and cardiac remodeling, making it a potential therapeutic target for hypertension and heart failure.
- Other names
- Clearance receptorNPRC
02
Mechanism of action
Receptor-mediated internalization and degradation of natriuretic peptides; modulation of adenylyl cyclase and phospholipase C signaling pathways.
03
Biological functions
Clearance of natriuretic peptidesReceptor-mediated internalizationRegulation of blood pressureAdenylyl cyclase inhibitionPhospholipase C activation
04
Disease associations
Cardiovascular diseaseHeart failureHypertensionCardiac remodelingAtrial fibrillation
05
Safety considerations
Alterations in expression/function can have significant cardiovascular consequences
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