Natriuretic Peptide Replacements (N/A)

Natriuretic peptide replacements are engineered molecules designed to replicate or enhance the beneficial cardiovascular/renal actions of natural NPs through activation of specific guanylyl cyclase-coupled receptors leading to increased cGMP signaling. Ongoing research aims at optimizing these agents’ pharmacokinetics/dynamics for safer long-term use across various cardiorenal diseases.

Other names

Synthetic Natriuretic PeptidesANP AnalogsBNP AnalogsCNP AnalogsNesiritideAnaritideMANPCD-NP

Activation of particulate guanylyl cyclase receptors (NPR-A/B), leading to increased intracellular cGMP, vasodilation, and enhanced renal sodium/water excretion.