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Target intelligence / Profile preview
Natural Cytotoxicity Receptor 1 (NCR1)
- Target
- NCR1
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane protein, Receptor
01
Overview
NKp46, also known as Natural Cytotoxicity Receptor 1 (NCR1), is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is primarily expressed on natural killer (NK) cells, but can also be found on certain subsets of T cells and innate lymphoid cells (ILCs). NKp46 plays a central role in the activation and regulation of NK cell-mediated cytotoxicity against tumor cells, virus-infected cells, and some pathogens.
- Other names
- NKp46
02
Mechanism of action
NKp46 engagement leads to activation signals that result in target cell lysis. The transmembrane arginine allows association with ITAM-containing adaptor proteins such as CD3ζ or FcRγ for signal transduction.
03
Biological functions
Immune responseCell-mediated cytotoxicitySignal transductionCytokine secretionImmune synapse formation
04
Disease associations
CancerInfectionLeukemiaReproductive failure
05
Safety considerations
Potential for off-target effects due to broad ligand recognitionRisk of cytokine storm upon excessive NK cell activation
06
Biomarkers
Expression levels as diagnostic/prognostic marker in infections, leukemia, tumors, reproductive failure
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