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Target intelligence / Profile preview
Natural Cytotoxicity Triggering Receptor 1 (NKp46)
- Target
- NKp46
- Molecular classification
- Type I transmembrane glycoprotein, Natural cytotoxicity receptor (NCR)
01
Overview
Natural cytotoxicity triggering receptor 1, commonly known as NKp46, is a major activating receptor found primarily on the surface of natural killer (NK) cells. It plays a central role in the immune system’s ability to recognize and eliminate virus-infected cells, tumor cells, and other abnormal or stressed target cells. Upon binding to its ligands, NKp46 triggers activation of NK cell cytolytic functions and cytokine production.
- Other names
- NCR1
02
Mechanism of action
Ligand binding triggers ITAM-dependent signaling cascade, leading to NK cell activation and target cell lysis.
03
Biological functions
Activation of cytotoxicityImmune synapse formationCytokine productionAnti-tumor immunityAnti-microbial defenseImmune regulation
04
Disease associations
Viral infections (HBV/HCV/HIV)LeukemiaTumorsAutoimmunityInflammation
05
Safety considerations
Potential for off-target effects on normal cellsRisk of cytokine storm if excessively activatedPossible contribution to autoimmunity/inflammation
06
Biomarkers
NKp46 expression levels in viral infectionsNKp46 expression levels in leukemiaNKp46 expression levels in tumors
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