Natural cytotoxicity triggering receptor 1 pseudogene

The natural cytotoxicity triggering receptor 1 pseudogene (ENSG00000226570) is a non-functional genomic sequence related to the protein-coding gene NCR1, which encodes NKp46 (CD335), a major receptor on natural killer (NK) cells that mediates cytotoxic activity against tumor and pathogen-infected cells. Being a pseudogene, ENSG00000226570 does not produce a functional protein and has no known therapeutic, biomarker, or drug interaction roles. The true therapeutic target is NCR1 (ENSG00000189430), not the pseudogene. Pseudogenes such as ENSG00000226570 are typically characterized by mutations or deletions that prevent protein production or function, and are not considered valid drug targets or biomarkers. The actual therapeutic and immunological significance comes from the functional gene NCR1 and its protein, NKp46. The true NKp46 (NCR1/CD335/LY94) is a well-validated immunological receptor, involved in NK cell activation and cancer immunotherapy research. ENSG00000226570 is a pseudogene, not a valid therapeutic target. For functional or drug discovery information, users should refer to the protein-coding NCR1 gene instead.

Other names

NCR1 pseudogeneNCR1PENSG00000226570Natural killer cell p46-related protein pseudogene