Natural cytotoxicity triggering receptor 2 ligands

“Natural cytotoxicity triggering receptor 2 ligands” refers collectively to the **ligands** that bind to **natural cytotoxicity triggering receptor 2 (NCR2 / NKp44)**, an activating receptor expressed mainly on human natural killer (NK) cells.[6][7][5] NCR2 itself is a type I transmembrane receptor with an extracellular Ig-like domain that associates with adaptor molecules to transduce activating signals, but “NCR2 ligands” is not a single, well-defined molecular entity; instead, multiple, structurally unrelated ligands on target cells (such as tumor cells, virus‑infected cells, or stressed cells, including a ligand described on astrocytes) can engage NKp44 and modulate NK cell cytotoxicity and cytokine production.[3][5][6] Because the query groups all ligands together rather than specifying one molecular species, it is not a properly canonical single target name and should be treated as an imprecise/aggregate term rather than a unique drug target.

Other names

Ligands of natural cytotoxicity receptor NKp44NKp44 ligandsNCR2 ligands