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Target intelligence / Profile preview
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1)
- Target
- NCR3LG1
- Molecular classification
- B7 family, Type I transmembrane protein, Receptor ligand
01
Overview
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1), also known as B7-H6, is a ligand for the natural cytotoxicity receptor NKp30 found on natural killer (NK) cells. It is a type I transmembrane protein belonging to the B7 family. Unlike many B7 family members, B7-H6 is not constitutively expressed in normal tissues but is frequently upregulated in tumor cells, making it a potential target for cancer immunotherapy. Upon binding to NKp30, it triggers NK cell activation and promotes the lysis of target cells expressing the ligand.
- Other names
- B7-H6B7 homolog 6NKp30 ligand
02
Mechanism of action
Binds to NKp30 receptor on NK cells, activating cytotoxic activity against target cells.
03
Biological functions
Immune responseNK cell activationTarget cell lysisCell-mediated cytotoxicity
04
Disease associations
CancerSepsis
05
Safety considerations
Potential for off-target effects if targeted therapeutically due to expression on some immune cells under pathological conditions.
06
Biomarkers
Cancer detectionPrognosis in neuroblastoma
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