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Target intelligence / Profile preview
Natural Killer Cell Receptor 2B4 (CD244)
- Target
- CD244
- Molecular classification
- Receptor, SLAM family, Ig superfamily, Transmembrane receptor
01
Overview
CD244 (2B4, SLAMF4) is a transmembrane receptor expressed on NK cells, T cells, and other immune cells. It interacts with CD48 and regulates immune cell function, providing either activating or inhibitory signals that modulate cytotoxicity, cytokine secretion, and intercellular interactions. Dysregulation of CD244 has been implicated in cancer, autoimmune diseases, and chronic infections.
- Other names
- 2B4SLAMF4
02
Mechanism of action
Modulation of NK cell and T cell activity through interaction with CD48, leading to activating or inhibitory signals depending on adaptor protein recruitment (SAP, SHP1/2, SHIP, EAT2).
03
Biological functions
Immune responseCytotoxicityCytokine secretionT-cell activation/inhibitionNK-cell activation/inhibitionIntercellular interactionsSignal transduction
04
Disease associations
CancerAutoimmunityChronic infectionInflammationImmune dysregulation
05
Safety considerations
Potential for immune-related adverse events due to modulation of NK cell and T cell activity.Risk of exacerbating autoimmune disorders or impairing anti-tumor immunity depending on the specific therapeutic approach.
06
Biomarkers
CD244 expression levels on NK cells and T cells as potential biomarkers for immune status and disease progression.CD48 expression levels on target cells.
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