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Target intelligence / Profile preview
Natural Killer Cell Receptor CD16 (CD16)
- Target
- CD16
- Molecular classification
- Receptor, Immunoglobulin superfamily
01
Overview
CD16 (FcγRIII) is a key surface receptor expressed on NK cells, neutrophils, monocytes, and macrophages. It mediates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of IgG antibodies, leading to the activation of immune effector cells and the elimination of antibody-coated target cells. There are two main isoforms: CD16a (FcγRIIIA), a transmembrane protein, and CD16b (FcγRIIIB), a GPI-anchored protein. CD16 is a crucial target in cancer immunotherapy strategies that enhance ADCC for improved tumor clearance. Its surface expression is regulated post-activation.
- Other names
- Fc gamma receptor IIIFcγRIIIFCGR3AFCGR3BFcγRIIIAFcγRIIIB
02
Mechanism of action
Binds to the Fc region of IgG antibodies, triggering NK cell activation and ADCC.
03
Biological functions
Immune responseAntibody-dependent cellular cytotoxicity (ADCC)Signal transductionCytokine productionPhagocytosis
04
Disease associations
CancerInfectionInflammationAutoimmune diseases
05
Safety considerations
Cytokine release syndrome (CRS)Off-target effects of ADCCVariability in patient response due to genetic polymorphisms
06
Interacting drugs
Therapeutic monoclonal antibodies (e.g., Rituximab, Trastuzumab)
1 more in the full profile.
07
Biomarkers
CD16 expression levelCD16a/CD16b polymorphism
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