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Target intelligence / Profile preview
Natural Killer Cell Receptor NKp30 (NKp30)
- Target
- NKp30
- Molecular classification
- Receptor, Type I transmembrane protein, Immunoglobulin-like receptor
01
Overview
NKp30 (NCR3, CD337) is a key activating receptor expressed on human natural killer (NK) cells. It plays a crucial role in innate immunity and immunosurveillance by recognizing stress-induced ligands on tumor or infected cells, triggering cytotoxic degranulation and cytokine secretion. It is a target for cancer immunotherapy including CAR-NK cell approaches.
- Other names
- NCR3CD337Natural Cytotoxicity Receptor 3Cluster of Differentiation 337
02
Mechanism of action
Activation of NK cell cytotoxicity and cytokine release upon ligand binding.
03
Biological functions
Immune responseCytotoxicityCytokine productionImmunosurveillanceNK cell activationSignal transduction
04
Disease associations
CancerInfectionAutoimmune diseasesPrimary Sjögren's syndrome
05
Safety considerations
Potential for off-target effects in immunotherapy.Immune-related adverse events in CAR-NK cell therapy.
06
Biomarkers
NKp30 expression levels on NK cells
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