Target intelligence / Profile preview

Natural Killer Cell Receptor NKp44 (NKp44)

Target: NKp44
Molecular classification: Receptor, Transmembrane glycoprotein, Natural Cytotoxicity Receptor (NCR)

Overview

NKp44 (NCR2, CD336) is an activating receptor expressed on activated natural killer (NK) cells and some innate lymphoid cell subsets. It belongs to the natural cytotoxicity receptor (NCR) family and plays a critical role in recognizing and eliminating virus-infected and tumor cells. Upon ligand binding, NKp44 signals through the DAP12 adaptor protein to trigger NK cell effector functions. The receptor interacts with both activating and inhibitory ligands, such as PCNA, which can modulate its activity.

Other names: NCR2CD336

Mechanism of action

Activation of NK cells leading to degranulation and cytokine production.

Biological functions

Immune responseCytotoxicityNK cell activationSignal transductionTissue homeostasisImmune regulation

Disease associations

CancerViral infectionAutoimmunity

Safety considerations

Potential for off-target effects due to expression on certain ILC subsets.Possible immune-related adverse events due to NK cell activation.

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