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Target intelligence / Profile preview
Natural Killer Cell Receptor NKp46 (NKp46)
- Target
- NKp46
- Molecular classification
- Receptor, Type I transmembrane glycoprotein, Immunoglobulin-like receptor
01
Overview
NKp46 (NCR1) is a major activating receptor expressed on natural killer (NK) cells and some non-NK innate lymphoid cells. It recognizes ligands on stressed, infected, or transformed cells, triggering NK cell cytotoxicity and cytokine production. NKp46 plays a critical role in antiviral and antitumor immunity and is explored as a therapeutic target using bispecific antibodies and NK cell engagers.
- Other names
- NCR1
02
Mechanism of action
Engagement of NKp46 leads to activation signals through associated adaptor proteins (FcεRIγ and CD3ζ), resulting in degranulation and cytokine production. Bispecific antibodies and NK cell engagers facilitate NK cell activation and target cell killing via NKp46 engagement.
03
Biological functions
Immune responseCytotoxicitySignal transductionCell killingCytokine productionActivating receptor function
04
Disease associations
Viral infectionsCancerAutoimmune diseasesHematological malignanciesReproductive failuresTransplantation
05
Safety considerations
Potential for off-target effects with NK cell-based therapiesCytokine release syndromeAlloimmune responsesOn-target, off-tumor toxicity
06
Interacting drugs
Bispecific antibodies
3 more in the full profile.
07
Biomarkers
NKp46 expression levels (high/low) as a prognostic indicator for viral infections, tumors, hematological malignancies, reproductive failures, autoimmune diseases
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