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Target intelligence / Profile preview
Natural killer group 2 member D ligand-expressing immunosuppressive cell
- Molecular classification
- Immune cell
01
Overview
Natural killer group 2 member D (NKG2D) ligand-expressing immunosuppressive cells are immune cells that express ligands for the NKG2D receptor, a potent activating receptor found on natural killer (NK) cells and certain T cell subsets. The expression of these ligands can have both immunostimulatory and immunosuppressive effects depending on the context and cell type involved. These cells contribute to immunosuppression by downregulating or inhibiting effector functions of NK and T cells through persistent or repeated engagement of NKG2D.
02
Biological functions
Immune suppressionImmune modulationAntigen presentationRegulation of cytotoxic lymphocyte activity
03
Disease associations
CancerAutoimmunityChronic inflammationInfection
04
Safety considerations
Potential for immune-related adverse events due to modulation of NK and T cell activityRisk of exacerbating autoimmune conditions
05
Biomarkers
MICAMICBULBP1ULBP2ULBP3ULBP4ULBP5ULBP6
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