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NAV2 antisense RNA 1 (NAV2-AS1)

Target: NAV2-AS1
Molecular classification: long non-coding RNA (lncRNA), natural antisense transcript (NAT)

Overview

NAV2 antisense RNA 1 (NAV2-AS1) is a long non-coding RNA transcribed from the opposite (antisense) strand of the NAV2 gene. As a natural antisense transcript (NAT), NAV2-AS1 regulates gene expression at different stages, including transcription and alternative splicing, and is part of a family of RNAs with emerging importance in epigenetic regulation and disease biology. While the biological function of NAV2-AS1 specifically is not fully characterized, NATs as a group are implicated in regulating gene activity, modulating chromatin organization, and contributing to pathogenic processes such as cancer and cardiovascular disease. NAV2-AS1 is not a conventional drug target, and no interacting drugs, mechanisms, or clinical biomarker applications have been reported at present.

Other names: NAV2-AS1ENSG00000254894HGNC:40744NCBI Gene:100874015

Biological functions

regulation of gene expression (cis and trans)transcriptional interferencecontrol of alternative splicingchromatin modification and epigenetic regulation

Disease associations

potential implication in cancer, by analogy to other antisense lncRNAs (NATs) that modulate tumor suppressor genesimplicated in cancer (as a class of NATs)implicated in cardiovascular disease (as a class of NATs)implicated in diabetes (as a class of NATs)implicated in neurological disorders (as a class of NATs)

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