NBPF member 25, pseudogene (NBPF25P)

NBPF member 25, pseudogene (NBPF25P) is a member of the neuroblastoma breakpoint family (NBPF), a large gene family characterized by multiple segmental duplications in the human genome, mostly on chromosome 1[1][2][3][4]. NBPF25P is classified as a pseudogene, meaning it does not encode a functional protein due to frameshift or nonsense mutations in its coding sequence[1][2]. Pseudogenes like NBPF25P may be transcribed but typically lack protein-coding capacity. There is currently no evidence that NBPF25P functions as a receptor, enzyme, transporter, or direct therapeutic target[1][3][4]. Its closest functional relatives in the NBPF family have been studied in the context of neuroblastoma and other diseases—including roles in brain development, cognitive disability, autism, and schizophrenia, largely via gene dosage effects of protein-coding family members and associated copy number variants[2][4]. However, these disease links do not apply directly to NBPF25P as it is non-functional as a protein and not a direct drug target. Notes: - NBPF25P is not a therapeutic target and is instead annotated as a non-functional genomic locus (pseudogene), explaining why all fields regarding function, mechanism, and drugs are null[1][3][4]. - This entity is sometimes included in gene panels or genomic and transcriptomic studies due to proximity to relevant functional NBPF genes but should not be confused with active protein-coding genes[2][4]. - As a pseudogene, it does not belong to conventional classes such as "receptor", "transporter", or "enzyme" and has no validated function or druggability.

Other names

NBPF25P