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Target intelligence / Profile preview
Nck Adaptor Protein (Nck)
- Target
- Nck
- Molecular classification
- Adaptor protein, Scaffolding protein
01
Overview
Nck proteins are adaptor molecules crucial for intracellular signal transduction. They consist of Nck1 and Nck2, which share high sequence similarity. Nck proteins are composed of three SH3 domains and one SH2 domain, facilitating protein-protein interactions that regulate actin cytoskeleton remodeling, cell migration, immune cell activation, and gene expression. They are primarily cytoplasmic and play a key role in linking receptor tyrosine kinases to downstream effectors. Dysregulation of Nck function is associated with diseases such as Wiskott-Aldrich Syndrome and tumor invasiveness.
- Other names
- NCK1NCKαNCK Adaptor Protein 1NCK2NCKβGrb4
02
Mechanism of action
N/A
03
Biological functions
Signal transductionActin cytoskeleton remodelingCell migrationCell-matrix adhesionIntercellular junctionsImmune cell activationGene expression regulation
04
Disease associations
Wiskott-Aldrich SyndromeVaccinia infection susceptibilityGlucose intoleranceTumor invasiveness
05
Safety considerations
Functional redundancy complicates targeted drug development.Dysregulation linked to tumor invasiveness.
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