NCOA7 antisense RNA 1 (NCOA7-AS1)

NCOA7 antisense RNA 1 (NCOA7-AS1) is a long non-coding RNA (lncRNA) that originates from the NCOA7 locus on chromosome 6 (chr6:125797856-125818858, according to hg38)[5]. It is distinct from protein-coding NCOA7 transcripts and is specifically classified as an "antisense RNA" because it is transcribed from the strand opposite to the coding NCOA7 gene[5].\nNCOA7-AS1 has been reported as inducible by type I interferons, most notably IFN-β, in peripheral blood mononuclear cells, CNS cell lines, and fetal brain cells[1]. Its induction depends on JAK-STAT pathway activation following interferon receptor engagement. Structurally, NCOA7-AS1 encodes a unique transcript comprising only the last five exons of the full-length NCOA7 gene plus a distinct first exon (exon 10a), which shows homology to bacterial aldo-keto oxidoreductase domains, conferring potential oxidation resistance activity[1].\nFunctionally, NCOA7-AS1 appears to contribute to cellular resistance against inflammation-mediated oxidative stress and may play a role in regulating immune responses and cellular redox balance, especially in the context of neuroinflammatory processes such as those seen in multiple sclerosis[1].\nThere is no current evidence or consensus to classify NCOA7-AS1 as a canonical therapeutic target (e.g., receptor, enzyme, transporter)[1][5]. No specific drugs are known to act directly on or target this lncRNA, and its potential as a biomarker or drug target remains investigational.

Other names

NCOA7-AS1NCOA7 antisense RNA 1ENSG00000232131